study of the effect of dexamethasone on the neural tube development in the Swiss albino mice embryos

Current study includes an investigation of the effects Dexamethasone (Dex) drug on neural tube development. A total 60 pregnant mice were allocated into four groups at random, with 15 each group, While control group received injections a Normal Saline 0.9 %, group's members given specified dose and different times. All animals their doses through tail intravenous injection specific periods pregnancy then embryos isolated embryonic days . The results various dexamethasone reveal that number concentration have increasing negative development mouse embryos, abnormalities (NTDs), Spina bifida, convoluted body tail, spina bifida cystica, porous longitudinal section in tube, general external morphological characteristics also influenced by Dex. Dex has harmful particularly when administered over extended period time many dosages.